Lieping Chen, MD, PhD - Publications
Publications (2000-present)
1. Tamada K, Shimozaki K, Chapoval AI, Zhu G, Sica G, Flies
D, Boone T, Hsu H, Fu YX, Nagata S, Ni J and Chen L. Modulation
of T cell-mediated immunity in tumor and graft versus host
disease models through LIGHT costimulatory pathway. Nature
Med. 6:283-289, 2000. Selected for highlight article
2. Tamada K, Shimozaki K, Chapoval A I, Zhai YF, Su J, Chen
SF, Hsieh SL, Nagata S, Ni J and Chen L. LIGHT, a tumor necrosis
factor-like molecule, costimulates T cell proliferation and
is required for dendritic cell-mediated allogeneic T cell response.
J. Immunol. 164:4105-4110, 2000
3. Chapoval AI, Tamada K and Chen L. Activated human dendritic
cells inhibit the growth of broad spectrum of tumor cell lines
in vitro. Blood 95:2346-2351, 2000
4. Martinet O, Ermekova V, Qiao JQ, Sauter B, Mandeli J, Chen
L and Chen SH. Immunomodulatory gene therapy with interleukin
12 and 4-1BB ligand: Long-term remission of liver metastases
in a mouse model. J. Natl. Cancer Inst. 92:931-936, 2000
5. Strome SE, Martin B, Flies DB, Tamada K, Chapoval AI, Dargent
DJ, Shu S and Chen L. Enhanced therapeutic potential of adoptive
immunotherapy by in vitro CD28/4-1BB costimulation of tumor
reactive T cells against a poorly immunogenic, MHC class I-negative
A9P melanoma. J. Immunotherapy 23:430-437, 2000
6. Chen SH, Pham-Nguyen KB, Martinet O, Huang Y, Yang W, Thung
SN, Chen L, Mittler R and Woo SLC. Rejection of disseminated
metastases of colon carcinoma by synergism of IL-12 gene therapy
and 4-1BB costimulation. Molecular Therapy 2:39-46, 2000
7. Wang S, Zhu G, Chapoval AI, Dong H, Tamada K, Ni J and Chen
L. Costimulation of T cells by B7-H2, a B7-like molecule that
binds ICOS. Blood 96:2808-2813, 2000
8. Chapoval AI, Zhu G and Chen L. Immunoglobulin fusion protein
as a tool for evaluation of T-cell costimulatory molecules.
Methods Mol. Med. 45: 247-255, 2000
9. Sica G and Chen L. Modulation of the immune response through
4-1BB. Adv. Exp. Med. Biol. 465:355-362, 2000. Invited review
article
10. Chen L. Novel costimulatory molecules and their application
in cancer medicine. In: Progress in Cell Biology and Immunology
of Cancer. Y. Guo, ed., Academy of Military Medical Sciences
Press, Beijing, pp30-39, 2000. Invited meeting report
11. Tamada K and Chen L. T lymphocyte costimulatory molecules
in host defense and immunologic diseases. Annals of Allergy
Asthma Immunol. 85:164-176, 2000 (Quiz 175-177). Invited review
article
12. Chen L and Wang H. Lymphocyte co-stimulation and its application
in cancer medicine. Bulletin Natl. Nat. Sci. Found. 14:328-331,
2000. Invited review article
13. Chapoval AI, Ni J, Lau JS, Wilcox RA, Flies DB, Dong H,
Sica GL, Zhu G, Tamada K and Chen L. B7-H3: A costimulatory
molecule for T cell activation and IFN-g production. Nature
Immunol. 2:269-274, 2001. Featured in News and View
14. Melero I, Mazzolini G, Narvaiza I, Qian C, Chen L and Prieto
J. IL-12 gene therapy for cancer: in synergy with other immunotherapies.
Trends Immunol. 22:113-116, 2001
15. Tamura H, Dong H, Zhu G, Sica GL, Flies DB, Tamada K and
Chen L. B7-H1 costimulation preferentially enhances CD28-independent
T helper functions. Blood 97:1809-1816, 2001
16. Sica G, Zhu G, Tamada K, Liu D, Ni J and Chen L. RELT,
A new member of tumor necrosis factor receptor superfamily,
is selectively expressed in hematopoietic tissues and activates
transcription factor NF-kB. Blood 97:2702-2707, 2001
17. Pakala SV, Llic A, Chen L and Sarvetnick N. TNF-a receptor
1 (p55) on islets is necessary for the expression of LIGHT
on diabetogenic T cells. Clin. Immunol. 100:198-207, 2001
18. Zhu G, Flies DB, Tamada K, Sun Y, Rodriguez M, Fu YX and
Chen L. Progressive depletion of peripheral B lymphocytes in
4-1BB (CD137) ligand/I-Ea transgenic mice. J. Immunol. 167:2671-2676,
2001
19. Khurana D, Martin EA, Kasperbauer JL, O'Malley BW Jr, Salomao
DR, Chen L and Strome SE. Characterization of a spontaneously
arising murine squamous cell carcinoma (SCC VII) as a prerequisite
for head and neck cancer immunotherapy. Head & Neck 23:899-906,
2001
20. Wang J, Chun T, Lo JC, Wu Q, Wang Y, Foster A, Roca K,
Chen M, Tamada K, Chen L, Wang CR and Fu YX. The critical role
of LIGHT, a tumor necrosis factor family member, in T cell
development. J. Immunol. 167:5099-5105, 2001
21. Wang J, Lo JC, Foster A, Yu P, Chen HM, Wang Y, Tamada
K, Chen L and Fu YX. The regulation of T-cell homeostasis and
autoimmunity by T cell-derived LIGHT. J. Clin. Invest. 108:1771-1780,
2001
22. Strome SE, Kawakami K, Alejandro D, Voss S, Kasperbauer
JL, Salomao D, Chen L, Maki RA and Puri RK. Interleukin 4 receptor-directed
cytotoxin therapy for human head and neck squamous cell carcinoma
in animal models. Clin. Cancer Res. 8:281-286, 2002
23. Sun Y, Wu Q, Lin X, Chen HM, Subudhi SK, Chen L and Fu
YX. Administration of agonistic anti-4-1BB monoclonal antibody
leads to the amelioration of experimental autoimmune encephalomyelitis.
J. Immunol. 168:1457-1465, 2002
24. Tamada K, Tamura H, Flies DB, Fu YX, Celis E, Pease LR,
Blazar BR and Chen L. Blockade of LIGHT/LTb and CD40 signaling
induces allospecific T cell anergy, preventing graft-versus-host
disease. J. Clin. Invest. 109:549-557, 2002. Selected for highlight
article
25. Strome SE, Martin E, Khurana D, Flies DB, Khurana D, Salamao
D, Tamada K, Chapoval AI, Kasperbauer JL, Olsen KD and Chen
L. Reassessment of CD62L as a marker of pre-effector T cells
in the tumor draining lymph nodes of head and neck cancer patients.
Otolaryngol. Head Neck Surg. 126:180-187, 2002
26. Wilcox RA, Flies DB, Zhu G, Johnson AJ, Tamada K, Chapoval
AI, Strome SE, Pease LR and Chen L. Provision of antigen and
CD137 signaling breaks immunological ignorance, promoting regression
of poorly immunogenic tumors. J. Clin. Invest. 109:651-659,
2002
27. Strome SE, Voss S, Wilcox RA, Wakefield TL, Tamada K, Chapoval
AI, Lu J, Kasperbauer J L, Padley D, Vile R, Gastineau D, Wettstein
PJ and Chen L. Strategies for antigen loading of dendritic
cells to enhance the antitumor immune response. Cancer Res.
62:1884-1889, 2002
28. Petroff MG, Chen L, Philips TA and Hunt JS. B7 family molecules:
Novel immunomodulators at the maternal-fetal interface. Placenta
23 (suppl. A): s95-s101, 2002
29. Wang SD, Zhu G, Tamada K, Chen L* and Bajorath J.* Ligand
binding sites of inducible costimulator and high avidity mutants
with improved function. J. Exp. Med. 195:1013-1041, 2002 (*Shared
senior authorship)
30. Wilcox RA, Chapoval AI, Gorski KS, Otsuji M, Shin T, Flies
DB, Tamada K, Mittler RS, Tsuchiya H, Pardoll DM and Chen L.
Cutting Edge: Expression of functional CD137 receptor by dendritic
cells. J. Immunol. 168:4262-4267, 2002
31. Wilcox RA and Chen L. Immunotherapy of human papillomavirus-associated
malignancies and the challenges posted by T-cell tolerance.
Front. Biosci. 7:d853-871, 2002. Invited review article
32. Chen L. Antibody gene therapy: Old wine in a new bottle.
Nature Med. 8: 333-334, 2002. Invited News and View article
33. Tamada K, Ni J, Zhu G, Fiscella M, Teng B, van Deursen
JMA and Chen L. Cutting Edge: Selective impairment of CD8+
T cell function in mice lacking the tumor necrosis factor superfamily
member LIGHT. J. Immunol. 168:4832-4835, 2002
34. Hsu TL, Chang YC, Chen SJ, Liu YJ, Chiu AW, Chio CC, Chen
L and Hsieh SL. Modulation of dendritic cell differentiation
and maturation by decoy receptor 3 (DcR3). J. Immunol. 168:4846-4853,
2002
35. May KF Jr, Chen L, Zheng P and Liu Y. Anti-4-1BB monoclonal
antibody enhances rejection of large tumor burden by promoting
survival but not clonal expansion of tumor-specific CD8+ T
cells. Cancer Res. 62:3459-3465, 2002
36. Chapoval AI, Zhu G and Chen L. Protocol: Immunoglobulin
fusion protein as a tool for evaluation of T-cell costimulatory
molecules. Mol. Biotechnol. 21:259-264, 2002
37. Dong H, Strome SE, Salomao DR, Tamura H, Hirano F, Flies
DB, Roche PC, Lu J, Zhu G, Tamada K, Lennon VA, Celis E and
Chen L. Tumor-associated B7-H1 promotes T-cell apoptosis: A
potential mechanism of immune evasion. Nature Med. 8:793-800,
2002 (Epub 2002 Jun 24). Featured in News and View article
38. Wilcox RA, Flies DB, Wang H, Tamada K, Johnson AJ, Pease
LR, Rodriguez M, Guo Y and Chen L. Impaired infiltration of
tumor-specific cytolytic T cells in the absence of interferon-g
despite their normal maturation in lymphoid organs during anti-CD137
monoclonal antibody therapy. Cancer Res. 62:4413-4418, 2002
39. Wilcox RA, Tamada K, Strome SE and Chen L. Signaling through
NK cell-associated CD137 promotes both helper function for
CD8+ cytolytic T lymphocytes and responsiveness to interleukin-2
but not cytolytic activity. J. Immunol. 169:4230-4236, 2002
40. Nguyen LT, Radhakrishnan S, Ciric B, Tamada K, Shin T,
Pardoll DM, Chen L, Rodriguez M and Pease LR. Cross-linking
the B7 family molecule B7-DC directly activates immune functions
of dendritic cells. J. Exp. Med. 196:1393-1398, 2002
41. Li XH, Li XD, Huang JY, Wei LX, Chen L, Wu MC and Guo YJ.
Antitumor immunity elicited by 4-1BBL gene transfected Hepa1-6
in vivo. Chinese J. Liver Dis. 10:409-412, 2002
42. Sun Y, Chen HM, Subudhi SK, Chen J, Koka R, Chen L and
Fu XY. Costimulatory molecule-targeted antibody therapy of
a spontaneous autoimmune disease. Nature Med. 8:1405-1413,
2002. Featured in News and View article
43. Dong H,* Strome SE,* Matteson EL, Moder KG, Flies DB, Tamura
H, Zhu G, Driscoll CW and Chen L. Costimulating aberrant T
cell responses by B7-H1 autoantibodies in rheumatoid arthritis.
J. Clin. Invest. 111:363-370, 2003 (*Equal contribution) Selected
for highlight article
44. Radhakrishnan S, Nguyen LT, Ciric B, Ure DR, Zhou B, Tamada
K, Dong H, Tseng SY, Pardoll DM, Chen L, Kyle RA, Rodriguez
M and Pease LR. Naturally occurring human monoclonal IgM antibody
that binds B7-DC and potentiates T cell stimulation by dendritic
cells. J. Immunol. 170:1830-1838, 2003
45. Wang S and Chen L. Immune regulatory functions of the B7-CD28
family molecules. Shanghai J. Immunol. 23:1-5, 2003. Invited
review article
46. Trabattoni D, Saresella M, Biasin M, Boasso A, Pacentini
L, Ferrante P, Villa ML, Dong H, Maserati R, Shearer GM, Chen
L and Clerici M. B7-H1 is upregulated in HIV infection and
is a novel surrogate marker of disease progression. Blood 101:2514-2520,
2003
47. Chen L. CD137 (4-1BB), more than a costimulator. Cancer
Immunol. Immunother. 52:s19-s20, 2003. Invited meeting report
48. Petroff MG, Chen L, Philips TA, Azzola D, Sedlmayr P and
Hunt JS. B7 family molecules are favorable positioned at the
human maternal-fetal interface. Biol. Reprod. 68:1496-1504,
2003
49. Kurosawa S, Myers AC, Chen L, Wang SD, Ni J, Plitt JR,
Heller NM, Bochner BS and Schleimer RP. Expression of the costimulatory
molecule B7-H2 (inducible costimulator ligand) by human airway
epithelial cells. Amer. J. Respir. Cell. Mol. Biol. 28:563-573,
2003
50. Flies DB and Chen L. A simple and rapid vortex method for
preparing antigen/adjuvant emulsions for immunization. J. Immunol.
Method. 276:239-242, 2003
51. Weinman EC, Roche PC, Kasperbauer JL, Cha SS, Sargent DJ,
Cheville J, Murphy LM, Chen L, Wettstein PJ, Gostout B, Ferrone
S and Strome SE. Characterization of antigen processing machinery
and survivin expression in tonsillar squamous cell carcinoma.
Cancer 97:2203-2211, 2003
52. Curiel TJ, Wei S, Dong H, Alvarez X, Krzysiek R, Cheng
J, Knuston K, Mottram P, Daniel B, Zimmermann MC, David O,
Burow M, Gordon A, Dhurandhar N, Myers L, Berggren R, Emilie
D, Alvarez RD, Hemminki A, Curiel DT, Lackner A, Chen L* and
Zou W.* Blockade of B7-H1 improves myeloid dendritic cell-mediated
anti-tumor immunity. Nature Med. 9:562-567, 2003 (*shared senior
authorship)
53. Wang SD,* Bajorath J,* Flies DB, Dong H, Honjo T and Chen
L. Molecular modeling and functional mapping of B7-H1 and B7-DC
uncouple costimulatory function from PD-1 interaction. J. Exp.
Med. 197:1083-1091, 2003 (Epub 2003 April 28) (*equal contribution)
54. Dong H and Chen L. B7-H1 pathway and its role in the evasion
of tumor immunity. J. Mol. Med. 81:281-289, 2003. Invited review
article
55. Sica GL,* Choi IH,* Zhu G, Tamada K, Wang S, Tamura H,
Chapoval AI, Flies DB, Bajorath J and Chen L. B7-H4, a molecule
of the B7 family, negatively regulates T-cell immunity. Immunity
18:849-861, 2003 (*Equal contribution)
56. Dong H, Tamura H, Wang SD and Chen L. Negative costimulatory
functions of B7-H1. In: The B7-CD28 Family Molecules. L. Chen,
ed., Molecular Biology Intelligence Unit, Eurekah.com/Landes
Bioscience/Kluwer Academic/Plenum Publisher. New York, NY.
p48-58, 2003
57. Chapoval AI and Chen L. B7-H3. In: The B7-CD28 Family Molecules.
L. Chen, Ed., Molecular Biology Intelligence Unit, Eurekah.com/Landes
Bioscience/Kluwer Academic/Plenum Publisher. New York, NY.
p91-99, 2003
58. Shin T, Kennedy G, Gorski K, Tsuchiya H, Koseki H, Azuma
M, Yagita H, Chen L, Powell J, Pardoll DM and Housseau F. Cooperative
B7-1/2 (CD80/CD86) and B7-DC costimulation of CD4+ T cells
independent of the PD-1 receptor. J. Exp. Med. 198:31-38, 2003
59. Zhu YW and Chen L. Cancer therapeutic monoclonal antibodies
targeting lymphocyte co-stimulatory pathways. Curr. Opin. Investig.
Drugs 4:691-695, 2003. Invited review article
60. Youngnak P, Kozono Y, Kozono H, Iwai H, Otsuki N, Jin H,
Omura K, Yagita H, Pardoll DM, Chen L and Azuma M. Differential
binding properties of B7-H1 and B7-DC to programmed death-1.
Biochem. Biophys. Res. Commun. 307:672-677, 2003
61. Rajagopalan G, Kudva YC, Chen L, Wen L and David CS. Autoimmune
diabetes in HLA-DR3/DQ8 transgenic mice expressing the co-stimulatory
molecule B7-1 in b cells of islets of Langerhans. Int. Immunol.
15:1035-1044, 2003
62. Wiendl H, Mitsdoerffer M, Schneider D, Chen L, Lochmüller
H, Melms A and Weller M. Human muscle cells express B7-H1 with
strong negative immunoregulatory potential: a novel mechanism
of counterbalancing the immune attack in idiopathic inflammatory
myopathies. FASEB J. 17:1892-1894, 2003
63. Kanai T, Totsuka T, Uraushihara K, Makita S, Nakamura T,
Koganei K, Fukushima T, Akiba H, Yagita H, Okumura K, Machida
U, Iwai H, Azuma M, Chen L and Watanabe M. Blockade of B7-H1
suppresses the development of chronic intestinal inflammation.
J. Immunol. 171:4156-4163, 2003
64. Strome SE,* Dong H,* Tamura H, Voss SG, Flies DB, Tamada
K, Salomao D, Cheville J, Hirano F, Lin W, Kasperbauer JL,
Ballman KV and Chen L. B7-H1 blockade augments adoptive T-cell
immunotherapy for squamous cell carcinoma. Cancer Res. 63:6501-6505,
2003 (*Equal contribution)
65. Choi IH, Zhu G, Sica G, Strome SE, Cheville JC, Lau JS,
Zhu YW, Flies DB, Tamada K and Chen L. Genomic organization
and expression analysis of B7-H4, an immune inhibitory molecule
of the B7 family. J. Immunol. 171:4650-4654, 2003
66. Wintterle S, Schreiner B, Schneider D, Chen L, Meyermann
R, Weller M and Wiendl H. Expression of the B7-related molecule
B7-H1 by glioma cells: a potential mechanism of immune paralysis.
Cancer Res. 63:7462-7467, 2003
67. Lee I, Wang L, Wells AD, Ye Q, Han R, Dorf ME, Kuziel WA,
Rollins BJ, Chen L and Hancock WW. Blocking the monocyte chemoattractant
protein-1/CCR2 chemokine pathway induces permanent survival
of islet allografts through a programmed death-1 ligand-1-dependent
mechanism. J. Immunol. 171:6929-6935, 2003
68. Tamura H, Ogata K, Dong H and Chen L. Immunology of B7-H1
and its roles in human diseases. Int. J. Hematol. 78(4):321-328,
2003. Invited review article
69. Morris GP, Chen L and Kong YM. CD137 signaling interferes
with activation and function of CD4+CD25+ regulatory T cells
in induced tolerance to experimental autoimmune thyroiditis.
Cell. Immunol. 226:20-29, 2003
70. Wilcox RA, Tamada K, Flies DB, Zhu G, Chapoval AI, Blazar
BR, Kast WM and Chen L. Ligation of CD137 receptor prevents
and reverses established anergy of CD8+ cytolytic T lymphocytes
in vivo. Blood 103:177-184, 2004 (Epub 2003 Sept. 11)
71. Rietz C and Chen L. New B7 family members with positive
and negative costimulatory functions. Amer. J. Transplant.
4:8-14, 2004 (Epub 2003 Sept. 11). Invited review article
72. Tamada K and Chen L. Immunological ignorance in cancer.
In: Cancer Immunotherapy at the Crossroads: How Tumors Evade
Immunity and What Can Be Done. Finke JH and Bukowski RM. Eds,
Humana Press Inc., Totowa, New Jersey. p87-99, 2004
73. Strome SE and Chen L. Costimulation-based immunotherapy
for head and neck cancer. Curr. Treat. Options Oncol. 5(1):27-33,
2004. Invited review article
74. Anand S and Chen L. Control of autoimmune diseases by the
B7-CD28 family molecules. Curr. Pharm. Design 10(2):121-128,
2004. Invited review article
75. Subudhi SK, Zhou P, Yerian LM, Chin RK, Lo JC, Anders RA,
Sun Y, Chen L, Wang Y, Alegre ML and Fu YX. Local expression
of B7-H1 promotes organ-specific autoimmunity and transplant
rejection. J. Clin. Invest. 113:694-700, 2004
76. Dong H, Zhu G, Tamada K, Flies DB, van Deursen JMA and
Chen L. B7-H1 determines accumulation and deletion of intrahepatic
CD8+ T lymphocytes. Immunity 20:327-336, 2004
77. Zhang X, Schwartz JD, Guo X, Bhatia S, Cao E, Chen L, Zhang
ZY, Edidin MA, Nathenson SG and Almo SC. Structure and functional
analysis of the costimulatory receptor programmed death-1.
Immunity 20:337-347, 2004
78. Tirapu I, Arina A, Mazzolini G, Duarte M, Alfaro C, Feijoo
E, Qian C, Chen L, Prieto J and Melero I. Improving efficacy
of interleukin-12-tranfected dendritic cells injected into
murine colon carcinomas with anti-CD137 monoclonal antibodies
and alloantigens. Int. J. Cancer 110:51-60, 2004
79. Chen L. Co-inhibitory molecules of the B7-CD28 family in
the control of T cell immunity. Nature Rev. Immunol. 4:336-347,
2004. Invited review article
80. Schreiber K, Cannon RE, Karrison C, Beck-Engeser G, Huo
D, Tennant RW, Jensen H, Kast WM, Krausz T, Meredith SC, Chen
L & Schreiber H. Strong synergy between mutant ras and
human papillomavirus -16 E6/E7 in the development of primary
tumors. Oncogene 23:3972-3979, 2004
81. Ward IM, Reina-San-Martin B, Olaru A, Minn K, Tamada K,
Lau JS, Cascallo M, Chen L, Nussenzweig A, Livak F, Nussenzweig
MC and Chen J. 53BP1 is required for class switch recombination.
J. Cell. Biol. 165:459-464, 2004
82. Wang SD and Chen L. T lymphocyte co-signaling pathways
of the B7-CD28 family. Cell. Mol. Immunol. 1:37-42, 2004. Invited
review article
83. Wang SD and Chen L. Co-signaling molecules of the B7-CD28
family in positive and negative regulation of T lymphocyte
responses. Microbes Infect. 6:759-766, 2004. Invited review
article
84. Yao S and Chen L. Immunomodulation in cancer therapy. In:
The Oncogenomics Handbook: Understanding and Treating Cancer
in the 21st Century. Richard A. Shimkets and William J. LaRochelle,
Eds., Cancer Drug Discovery and Development Series, The Humana
Press Inc., Totowa, New Jersey. in press, 2004
85. Wilcox RA and Chen L. CD137 in innate and adaptive immunity.
In: Tumor Necrosis Factor Superfamily. S. Khare, ed., Medical
Intelligence Unit, R. G. Landes Co., Austin, TX. In press,
2004
86. Radhakrishnan S, Nguyen LT, Ciric B, Flies DB, Chen L,
Rodriguez M and Pease LR. Immunotherapeutic potential of B7-DC
cross-linking antibody in conferring anti-tumor immunity in
mice. Cancer Res. In press, 2004
87. Schreiner B, Mitsdoerffer M, Kieseier BC, Chen L, Hartung
HP, Weller M and Wiendl H. Interferon-b enhances monocyte and
dendritic cell expression of B7-H1 (PD-L1), a strong inhibitor
of autologous T cell activation: Relevance for the immune modulatory
effect in multiple sclerosis. J. Neuroimmunol. In press, 2004
88. Curiel TJ, Alvarez X, Chen P, Evdemon-Hogan M, Mottram
P, Burow M, Zhu Y, Wei S, Daniel B, David O, Borvak J, Emilie
D, Gordon A, Disis ML, Knuston K, Lackner A, Chen L and Zou
W. Specific recruitment of regulatory T cells fosters immune
privilege in ovarian carcinoma. Nature Med. In press, 2004
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